What is Naloxone? Naloxone, sometimes referred to by the brand name Narcan, is a medication administered to people who may be experiencing an opioid overdose. Suspected opiate overdose signs are severe breathing problems and unresponsiveness. Naloxone reverses the overdose by attaching to the opiate receptors in the brain. Learn more at https://www.narcan.com/#how-to-get-narcan. All 50 states